FISCHELL DEPARTMENT OF BIOENGINEERING
VASCULAR KINETICS LAB
Welcome to the Vascular Kinetics Lab at the University of Maryland
Our laboratory uses engineering methods to understand how integrated biochemical and biomechanical factors contribute to cardiovascular disease. Specifically, we change the biochemical environment (e.g., by changing glucose levels or extracellular matrix proteins) and measure how endothelial cells respond to mechanics (e.g., shear stress, cyclic strain, substrate stiffness). We also perturb the mechanical environment and measure how endothelial cells respond to biochemical signals, such as angiogenic growth factors. We currently study how vascular hemodynamics affect endothelial metabolism and how this varies in subjects of different sex and race. Our work integrates in vitro, ex vivo, in vivo, and in silico methods. We collaborate with investigators from diverse fields, including mechanical, chemical, and electrical engineering, kinesiology, biology, physics, and cardiovascular surgery. To learn more about our research, click here.
We believe that science and engineering benefit from diverse voices and an open, inclusive environment. Each individual adds to our lab culture in unique ways, and we are all constantly learning how to build equity into bioengineering research and education. As a lab, we believe that science and engineering benefit from diverse voices and an open, inclusive environment. To find out more information for open positions, please click here or send an email to aclyne@umd.edu.
Our focus on the impact of social inequality on human health was featured in the “UMD Engineers Rise Up to Grand Challenges of 2020” video